There is substantial variation in prescribing behaviours, across various different areas of medicine. Some variation can be explained by demographic changes, or local policies or guidelines, but much of the remaining variation is less easy to explain. At OpenPrescribing we are piloting a number of data-driven approaches to identify unusual prescribing and collect feedback on this prescribing to inform development of new tools to support prescribers and organisations to audit and review prescribing.
This report has been developed to automatically identify prescribing patterns at a chemical level which are furthest away from “typical prescribing” and can be classified as an “outlier”. We calculate the number of prescriptions for each chemical in the BNF coding system using the BNF subparagraph as a denominator, for prescriptions dispensed between April 2021 and August 2021. We then calculate the mean and standard deviation for each numerator and denominator pair across all practices/CCGs/PCNs/STPs. From this we can calculate the “z-score”, which is a measure of how many standard deviations a given practice/CCG/PCN/STP is from the population mean. We then rank your “z-scores” to find the top 5 results where prescribing is an outlier for prescribing higher than its peers and those where it is an outlier for prescribing lower than its peers.
It is important to remember that this information was generated automatically and it is therefore likely that some of the behaviour is warranted. This report seeks only to collect information about where this variation may be warranted and where it might not. Our full analytical method code is openly available on GitHub here.
The DataLab is keen to hear your feedback on the results. You can do this by completing the following survey or emailing us at ebmdatalab@phc.ox.ac.uk. Please DO NOT INCLUDE IDENTIFIABLE PATIENT information in your feedback. All feedback is helpful, you can send short or detailed feedback.
BNF Chemical | Chemical Items | BNF Subparagraph | Subparagraph Items | Ratio | Mean | std | Z_Score | Plots |
---|---|---|---|---|---|---|---|---|
Exenatide | 213 | Other antidiabetic drugs | 3879 | 0.05 | 0.01 | 0.01 | 9.29 | |
Exenatide 10micrograms/0.04ml inj 2.4ml pf dispos dev : 8 Exenatide 2mg inj pre-filled disposable devices : 14 Exenatide 2mg/0.85ml prolonged-release inj pf dispos dev : 4 Byetta 10micrograms/0.04ml inj 2.4ml pre-filled pens : 9 Bydureon 2mg inj pre-filled pens : 5 Bydureon BCise 2mg/0.85ml prolonged-release inj pf pens : 173 | ||||||||
Denosumab | 226 | Bisphosphonates and other drugs | 1542 | 0.15 | 0.01 | 0.02 | 7.14 | |
Triptorelin embonate | 50 | Prostate cancer and gonadorelin analogues | 182 | 0.27 | 0.02 | 0.04 | 5.96 | |
Pentazocine hydrochloride | 10 | Opioid analgesics | 6360 | 0.00 | 0.00 | 0.00 | 5.60 | |
Telmisartan | 536 | Angiotensin-II receptor antagonists | 5671 | 0.09 | 0.01 | 0.01 | 5.59 | |
BNF Chemical | Chemical Items | BNF Subparagraph | Subparagraph Items | Ratio | Mean | std | Z_Score | Plots |
---|---|---|---|---|---|---|---|---|
Carbimazole | 90 | Antithyroid drugs | 128 | 0.70 | 0.93 | 0.04 | -5.13 | |
Furosemide | 1850 | Loop diuretics | 3242 | 0.57 | 0.85 | 0.07 | -4.00 | |
Prednisolone | 1764 | Use of corticosteroids | 2329 | 0.76 | 0.88 | 0.03 | -3.90 | |
Prednisolone 1mg tablets : 383 Prednisolone 2.5mg tablets : 25 Prednisolone 5mg tablets : 1232 Prednisolone 2.5mg gastro-resistant tablets : 24 Prednisolone 5mg gastro-resistant tablets : 33 Prednisolone 25mg tablets : 6 Prednisolone 1mg gastro-resistant tablets : 1 Prednisolone 5mg soluble tablets : 51 Prednisolone 10mg tablets : 9 | ||||||||
Finasteride | 1075 | Male sex hormones and antagonists | 1652 | 0.65 | 0.83 | 0.07 | -2.41 | |
Folic acid | 1242 | Drugs used in megaloblastic anaemias | 3366 | 0.37 | 0.68 | 0.13 | -2.37 | |