Static outliers for NHS Buckinghamshire CCG

There is substantial variation in prescribing behaviours, across various different areas of medicine. Some variation can be explained by demographic changes, or local policies or guidelines, but much of the remaining variation is less easy to explain. At OpenPrescribing we are piloting a number of data-driven approaches to identify unusual prescribing and collect feedback on this prescribing to inform development of new tools to support prescribers and organisations to audit and review prescribing.

This report has been developed to automatically identify prescribing patterns at a chemical level which are furthest away from “typical prescribing” and can be classified as an “outlier”. We calculate the number of prescriptions for each chemical in the BNF coding system using the BNF subparagraph as a denominator, for prescriptions dispensed between April 2021 and August 2021. We then calculate the mean and standard deviation for each numerator and denominator pair across all practices/CCGs/PCNs/STPs. From this we can calculate the “z-score”, which is a measure of how many standard deviations a given practice/CCG/PCN/STP is from the population mean. We then rank your “z-scores” to find the top 5 results where prescribing is an outlier for prescribing higher than its peers and those where it is an outlier for prescribing lower than its peers.

It is important to remember that this information was generated automatically and it is therefore likely that some of the behaviour is warranted. This report seeks only to collect information about where this variation may be warranted and where it might not. Our full analytical method code is openly available on GitHub here.

The DataLab is keen to hear your feedback on the results. You can do this by completing the following survey or emailing us at ebmdatalab@phc.ox.ac.uk. Please DO NOT INCLUDE IDENTIFIABLE PATIENT information in your feedback. All feedback is helpful, you can send short or detailed feedback.

Prescribing where NHS Buckinghamshire CCG is higher than most

BNF Chemical Chemical Items BNF Subparagraph Subparagraph Items Ratio Mean std Z_Score Plots
Camellia sinensis extract 5 Preparations for warts and calluses 266 0.02 0.0 0.0 8.01
Sodium benzoate 5 Mouth-washes, gargles and dentifrices 346 0.01 0.0 0.0 7.49
Sultiame 24 Control of epilepsy 74187 0.00 0.0 0.0 7.36
Yellow fever 1 Vaccines and antisera 3918 0.00 0.0 0.0 6.66
Paracetamol and caffeine 7 Non-opioid analgesics and compound preparations 73057 0.00 0.0 0.0 5.30

Prescribing where NHS Buckinghamshire CCG is lower than most

BNF Chemical Chemical Items BNF Subparagraph Subparagraph Items Ratio Mean std Z_Score Plots
Levothyroxine sodium 102730 Thyroid hormones 103275 0.99 1.00 0.00 -3.36
Pregabalin 9248 Control of epilepsy 74187 0.12 0.28 0.05 -3.33
Pregabalin 25mg capsules : 1214
Pregabalin 50mg capsules : 1628
Pregabalin 75mg capsules : 1435
Pregabalin 100mg capsules : 1383
Pregabalin 150mg capsules : 1605
Pregabalin 200mg capsules : 443
Pregabalin 300mg capsules : 1188
Pregabalin 225mg capsules : 57
Pregabalin 150mg/5ml oral liquid : 5
Pregabalin 20mg/ml oral solution sugar free : 21
Pregabalin 25mg tablets : 60
Pregabalin 50mg tablets : 29
Pregabalin 100mg tablets : 12
Pregabalin 200mg tablets : 3
Pregabalin 75mg tablets : 75
Pregabalin 150mg tablets : 10
Pregabalin 225mg tablets : 5
Lyrica 25mg capsules : 13
Lyrica 50mg capsules : 11
Lyrica 75mg capsules : 8
Lyrica 100mg capsules : 6
Lyrica 150mg capsules : 5
Lyrica 300mg capsules : 13
Lyrica 20mg/ml oral solution : 9
Alzain 75mg capsules : 1
Alzain 100mg capsules : 1
Alzain 150mg capsules : 4
Alzain 300mg capsules : 4
Doxycycline hyclate 5854 Tetracyclines 12825 0.46 0.64 0.06 -2.92
Ropinirole hydrochloride 834 Dopaminergic drugs used in parkinsonism 12562 0.07 0.16 0.04 -2.68
Desogestrel 11518 Oral progestogen-only contraceptives 12686 0.91 0.95 0.02 -2.41