There is substantial variation in prescribing behaviours, across various different areas of medicine. Some variation can be explained by demographic changes, or local policies or guidelines, but much of the remaining variation is less easy to explain. At OpenPrescribing we are piloting a number of data-driven approaches to identify unusual prescribing and collect feedback on this prescribing to inform development of new tools to support prescribers and organisations to audit and review prescribing.
This report has been developed to automatically identify prescribing patterns at a chemical level which are furthest away from “typical prescribing” and can be classified as an “outlier”. We calculate the number of prescriptions for each chemical in the BNF coding system using the BNF subparagraph as a denominator, for prescriptions dispensed between April 2021 and August 2021. We then calculate the mean and standard deviation for each numerator and denominator pair across all practices/CCGs/PCNs/STPs. From this we can calculate the “z-score”, which is a measure of how many standard deviations a given practice/CCG/PCN/STP is from the population mean. We then rank your “z-scores” to find the top 5 results where prescribing is an outlier for prescribing higher than its peers and those where it is an outlier for prescribing lower than its peers.
It is important to remember that this information was generated automatically and it is therefore likely that some of the behaviour is warranted. This report seeks only to collect information about where this variation may be warranted and where it might not. Our full analytical method code is openly available on GitHub here.
The DataLab is keen to hear your feedback on the results. You can do this by completing the following survey or emailing us at ebmdatalab@phc.ox.ac.uk. Please DO NOT INCLUDE IDENTIFIABLE PATIENT information in your feedback. All feedback is helpful, you can send short or detailed feedback.
BNF Chemical | Chemical Items | BNF Subparagraph | Subparagraph Items | Ratio | Mean | std | Z_Score | Plots |
---|---|---|---|---|---|---|---|---|
Clozapine | 482 | Antipsychotic drugs | 43985 | 0.01 | 0.00 | 0.00 | 9.24 | |
Norethisterone enantate | 4 | Parenteral progestogen-only contraceptives | 4289 | 0.00 | 0.00 | 0.00 | 7.06 | |
Bupropion hydrochloride | 233 | Nicotine dependence | 392 | 0.59 | 0.08 | 0.09 | 5.93 | |
Dequalinium chloride | 1 | Lozenges and sprays | 13 | 0.08 | 0.00 | 0.01 | 5.49 | |
Macitentan | 1 | Vasodilator antihypertensive drugs | 386 | 0.00 | 0.00 | 0.00 | 5.43 | |
BNF Chemical | Chemical Items | BNF Subparagraph | Subparagraph Items | Ratio | Mean | std | Z_Score | Plots |
---|---|---|---|---|---|---|---|---|
Solifenacin | 3174 | Drugs for urinary frequency enuresis and incontinence | 33789 | 0.09 | 0.33 | 0.06 | -3.62 | |
Calcipotriol | 4113 | Preparations for psoriasis | 5280 | 0.78 | 0.87 | 0.03 | -3.25 | |
Calcipotriol 50micrograms/g ointment : 749 Calcipotriol 50micrograms/ml scalp solution : 160 Calcipotriol 0.005% / Betamethasone dipropionate 0.05% oint : 385 Calcipotriol 0.005% / Betamethasone dipropionate 0.05% gel : 354 Calcipotriol 50microg/Betamethasone diprop 500microg/g foam : 308 Dovonex 50micrograms/g ointment : 128 Dovobet ointment : 175 Dovobet gel : 328 Enstilar 50micrograms/g / 0.5 mg/g cutaneous foam : 1526 | ||||||||
Doxycycline hyclate | 7905 | Tetracyclines | 16966 | 0.47 | 0.64 | 0.06 | -2.77 | |
Betahistine hydrochloride | 3726 | Drugs used in nausea and vertigo | 23776 | 0.16 | 0.29 | 0.05 | -2.38 | |
Rifaximin | 50 | Some other antibacterials | 1479 | 0.03 | 0.45 | 0.18 | -2.26 | |