Static outliers for NHS Bolton CCG

There is substantial variation in prescribing behaviours, across various different areas of medicine. Some variation can be explained by demographic changes, or local policies or guidelines, but much of the remaining variation is less easy to explain. At OpenPrescribing we are piloting a number of data-driven approaches to identify unusual prescribing and collect feedback on this prescribing to inform development of new tools to support prescribers and organisations to audit and review prescribing.

This report has been developed to automatically identify prescribing patterns at a chemical level which are furthest away from “typical prescribing” and can be classified as an “outlier”. We calculate the number of prescriptions for each chemical in the BNF coding system using the BNF subparagraph as a denominator, for prescriptions dispensed between April 2021 and August 2021. We then calculate the mean and standard deviation for each numerator and denominator pair across all practices/CCGs/PCNs/STPs. From this we can calculate the “z-score”, which is a measure of how many standard deviations a given practice/CCG/PCN/STP is from the population mean. We then rank your “z-scores” to find the top 5 results where prescribing is an outlier for prescribing higher than its peers and those where it is an outlier for prescribing lower than its peers.

It is important to remember that this information was generated automatically and it is therefore likely that some of the behaviour is warranted. This report seeks only to collect information about where this variation may be warranted and where it might not. Our full analytical method code is openly available on GitHub here.

The DataLab is keen to hear your feedback on the results. You can do this by completing the following survey or emailing us at ebmdatalab@phc.ox.ac.uk. Please DO NOT INCLUDE IDENTIFIABLE PATIENT information in your feedback. All feedback is helpful, you can send short or detailed feedback.

Prescribing where NHS Bolton CCG is higher than most

BNF Chemical Chemical Items BNF Subparagraph Subparagraph Items Ratio Mean std Z_Score Plots
Carglumic acid 1 Drugs used in metabolic disorders 8 0.12 0.00 0.01 9.27
Inosine pranobex 22 Herpes simplex and varicella-zoster 1775 0.01 0.00 0.00 8.53
Other otitis external preparations 10 Otitis externa 3166 0.00 0.00 0.00 8.40
Tiopronin 3 Rheumatic disease suppressant drugs 5449 0.00 0.00 0.00 7.41
Promazine hydrochloride 10430 Antipsychotic drugs 35907 0.29 0.01 0.04 6.65

Prescribing where NHS Bolton CCG is lower than most

BNF Chemical Chemical Items BNF Subparagraph Subparagraph Items Ratio Mean std Z_Score Plots
Ganciclovir 2 Antivirals 21 0.10 0.68 0.17 -3.40
Gliclazide 12187 Sulfonylureas 20278 0.60 0.92 0.11 -2.78
Mebeverine hydrochloride 3933 Antispasmodic and other drugs altering gut motility 11804 0.33 0.46 0.05 -2.69
Nystatin 1480 Polyene antifungals 1481 1.00 1.00 0.00 -2.41
Quetiapine 7637 Antipsychotic drugs 35907 0.21 0.36 0.06 -2.38
Quetiapine 25mg tablets : 1740
Quetiapine 100mg tablets : 1140
Quetiapine 200mg tablets : 792
Quetiapine 150mg tablets : 449
Quetiapine 300mg tablets : 633
Quetiapine 50mg modified-release tablets : 43
Quetiapine 200mg modified-release tablets : 66
Quetiapine 300mg modified-release tablets : 105
Quetiapine 400mg modified-release tablets : 76
Quetiapine 150mg modified-release tablets : 46
Quetiapine 25mg/5ml oral suspension : 6
Quetiapine 600mg modified-release tablets : 4
Seroquel 25mg tablets : 4
Seroquel 100mg tablets : 1
Seroquel XL 50mg tablets : 6
Seroquel XL 400mg tablets : 6
Sondate XL 50mg tablets : 359
Sondate XL 200mg tablets : 494
Sondate XL 300mg tablets : 717
Sondate XL 400mg tablets : 305
Sondate XL 150mg tablets : 143
Zaluron XL 200mg tablets : 6
Zaluron XL 300mg tablets : 1
Zaluron XL 400mg tablets : 4
Biquelle XL 50mg tablets : 126
Biquelle XL 150mg tablets : 48
Biquelle XL 200mg tablets : 79
Biquelle XL 300mg tablets : 114
Biquelle XL 400mg tablets : 71
Biquelle XL 600mg tablets : 21
Mintreleq XL 50mg tablets : 7
Mintreleq XL 300mg tablets : 19
Mintreleq XL 400mg tablets : 6