OpenDNA Report

Local precision-medicine synthesis · not for clinical use

Generated

2026-04-20

66 target SNPs · 9 confidently assessed

Source File Quality

These checks describe what this raw DNA file can and cannot support. Missing markers should be read as “not assessed,” not as a negative result.

Vendor

23andMe

Reference Build

GRCh37

Unique Rsids

11

No-Calls / Ambiguous

1 / 0

QC notes

• Warning: This raw DNA file is unusually small. Treat absent markers very cautiously; the file may be truncated or heavily filtered.
• Info: 1 markers were present in the file but had no confident genotype call.

Known blind spots for this file type

• Consumer array files only assay a tiny fraction of the genome, so normal here never rules out other variants in the same gene.
• This file type does not support rare-variant calling, structural variants, methylation, HLA typing, or most CYP2D6 star-allele inference.
• Chip versions vary, so absent markers often reflect array design rather than a true negative result.
• This file is good for common SNPs but still misses rare variants, structural variants, and most CYP2D6/HLA haplotypes.

Composite Calls

These combine multiple source-file markers into a single interpretation, which is usually more useful than reading each rsid in isolation.

MTHFR Composite

warning

MTHFR composite: likely compound heterozygous C677T/A1298C pattern, which can matter more than either single heterozygous call alone.

Genes: MTHFR

Inputs: rs1801131, rs1801133

Confidence: 100% · high

APOE Composite

normal

APOE composite: e3/e3. This is the baseline APOE pattern used for most population comparisons.

Genes: APOE

Inputs: rs429358, rs7412

Confidence: 100% · high

Panel Coverage

A section is only as good as the markers this file actually covered. These counts separate assessed markers from missing or unusable ones.

Athletic Performance & Recovery

1/5

assessed · 20%

Not on chip: 4

No-call: 0

Ambiguous: 0

Risk / Warning / Normal: 0 / 0 / 1

Cardiovascular & Longevity

2/8

assessed · 25%

Not on chip: 6

No-call: 0

Ambiguous: 0

Risk / Warning / Normal: 0 / 0 / 2

Cognition & Mood

1/3

assessed · 33%

Not on chip: 2

No-call: 0

Ambiguous: 0

Risk / Warning / Normal: 1 / 0 / 0

Dietary Sensitivity & Nutrition

0/6

assessed · 0%

Not on chip: 6

No-call: 0

Ambiguous: 0

Risk / Warning / Normal: 0 / 0 / 0

Eye Health & Macular Degeneration

0/3

assessed · 0%

Not on chip: 3

No-call: 0

Ambiguous: 0

Risk / Warning / Normal: 0 / 0 / 0

Iron Metabolism (HFE)

0/3

assessed · 0%

Not on chip: 3

No-call: 0

Ambiguous: 0

Risk / Warning / Normal: 0 / 0 / 0

Histamine Handling

0/5

assessed · 0%

Not on chip: 5

No-call: 0

Ambiguous: 0

Risk / Warning / Normal: 0 / 0 / 0

Methylation & Detox

3/8

assessed · 38%

Not on chip: 5

No-call: 0

Ambiguous: 0

Risk / Warning / Normal: 0 / 3 / 0

Nicotine Dependence & Smoking Response

0/3

assessed · 0%

Not on chip: 3

No-call: 0

Ambiguous: 0

Risk / Warning / Normal: 0 / 0 / 0

Pharmacogenomics (PGx)

1/14

assessed · 7%

Not on chip: 13

No-call: 0

Ambiguous: 0

Risk / Warning / Normal: 1 / 0 / 0

Stimulant & Adenosine Sensitivity

1/4

assessed · 25%

Not on chip: 3

No-call: 0

Ambiguous: 0

Risk / Warning / Normal: 0 / 1 / 0

Vitamin D & Bone

0/4

assessed · 0%

Not on chip: 4

No-call: 0

Ambiguous: 0

Risk / Warning / Normal: 0 / 0 / 0

Cross-Panel Gene View

These roll up duplicate or multi-marker genes so the analysis reads at the gene level, not just the panel level.

COMT

warning

Warrior phenotype — fast dopamine clearance; often higher stress resilience, lower baseline dopamine. Warrior — dopamine clears fast; stimulants may feel less intense.

Panels: Methylation & Detox, Stimulant & Adenosine Sensitivity

Rsids: rs4680

MTHFR

warning

MTHFR composite: likely compound heterozygous C677T/A1298C pattern, which can matter more than either single heterozygous call alone.

Panels: Methylation & Detox

Rsids: rs1801131, rs1801133

Boundary: Common MTHFR SNPs do not directly diagnose folate deficiency; homocysteine, B12, folate, and diet still matter.

APOE

normal

APOE composite: e3/e3. This is the baseline APOE pattern used for most population comparisons.

Panels: Cardiovascular & Longevity

Rsids: rs429358, rs7412

Boundary: APOE status here comes from rs429358 + rs7412 only; it does not capture non-APOE causes of dementia or lipid risk.

Athletic Performance & Recovery

1/5 assessed · 4 not on chip · 0 no-call · 0 ambiguous

ACTN3

normal

CT · rs1815739

RX — mixed profile.

Confidence: 100% · high via exact

Cardiovascular & Longevity

2/8 assessed · 6 not on chip · 0 no-call · 0 ambiguous

APOE

normal

TT · rs429358

Not e4 at this site.

Confidence: 100% · high via exact

Boundary: APOE status here comes from rs429358 + rs7412 only; it does not capture non-APOE causes of dementia or lipid risk.

ClinVar: risk factor — Alzheimer disease; cardiovascular disease

ClinVar review: reviewed by expert panel · ClinVar 2026-03 snapshot

APOE

normal

CC · rs7412

Not e2 at this site.

Confidence: 100% · high via exact

Boundary: APOE status here comes from rs429358 + rs7412 only; it does not capture non-APOE causes of dementia or lipid risk.

ClinVar: risk factor / protective — Type III hyperlipoproteinemia (homozygous e2)

ClinVar review: reviewed by expert panel · ClinVar 2026-03 snapshot

Cognition & Mood

1/3 assessed · 2 not on chip · 0 no-call · 0 ambiguous

BDNF

risk

TT · rs6265

Met/Met — reduced plasticity; aerobic exercise and novel learning particularly important.

Confidence: 100% · high via exact

Methylation & Detox

3/8 assessed · 5 not on chip · 0 no-call · 0 ambiguous

MTHFR

warning

CT · rs1801133

~30% reduced enzyme activity; monitor homocysteine.

Confidence: 100% · high via exact

Boundary: Common MTHFR SNPs do not directly diagnose folate deficiency; homocysteine, B12, folate, and diet still matter.

ClinVar: drug response — Homocystinuria; MTHFR deficiency

ClinVar review: reviewed by expert panel · ClinVar 2026-03 snapshot

MTHFR

warning

AC · rs1801131

Mild reduction; clinically meaningful only when combined with C677T variant.

Confidence: 100% · high via exact

Boundary: Common MTHFR SNPs do not directly diagnose folate deficiency; homocysteine, B12, folate, and diet still matter.

ClinVar: not provided — MTHFR deficiency (compound heterozygous with C677T)

ClinVar review: multiple submitters, no conflicts · ClinVar 2026-03 snapshot

COMT

warning

GG · rs4680

Warrior phenotype — fast dopamine clearance; often higher stress resilience, lower baseline dopamine.

Confidence: 100% · high via exact

Pharmacogenomics (PGx)

1/14 assessed · 13 not on chip · 0 no-call · 0 ambiguous

TPMT

risk

TT · rs1142345

Poor metabolizer — standard thiopurine doses can cause fatal myelosuppression. Requires dose reduction or alternative therapy.

Confidence: 100% · high via exact

Boundary: This panel captures TPMT *3C only; other TPMT and NUDT15 variants can still be clinically important.

ClinVar: drug response — Thiopurine S-methyltransferase deficiency

ClinVar review: reviewed by expert panel (PharmGKB) · ClinVar 2026-03 snapshot

Azathioprine: Consider alternative non-thiopurine therapy; if used, reduce dose 10-fold and monitor for severe myelosuppression.

PGx evidence: 1A · CPIC 2018

Mercaptopurine: Start at 30-80% of normal dose (heterozygote) or 10% of normal dose (homozygote).

PGx evidence: 1A · CPIC 2018

Thioguanine: Start at 50-80% of normal dose (heterozygote) or consider alternative (homozygote).

PGx evidence: 1A · CPIC 2018

Stimulant & Adenosine Sensitivity

1/4 assessed · 3 not on chip · 0 no-call · 0 ambiguous

COMT

warning

GG · rs4680

Warrior — dopamine clears fast; stimulants may feel less intense.

Confidence: 100% · high via exact