Sample report

This is a demo OpenDNA report rendered from a 23andMe-style raw DNA file. Every finding below is interpretation data drawn from the project's curated SNP panels + ClinVar + PharmGKB. When you run OpenDNA on your own machine, your raw DNA file is parsed and analyzed entirely offline; only if you opt in to AI synthesis does the tool send the filtered findings (not the raw DNA) to the LLM provider you choose. Full setup + privacy details at github.com/corbett3000/OpenDNA.

OpenDNA Report

Local precision-medicine synthesis · not for clinical use

Generated
2026-04-17
40 SNPs scanned · 38 with data
4
Risk
11
Warnings
23
Normal
2
Not in file

⚠ Critical findings

9p21 (rs10757278 GG): Two risk alleles — elevated CAD risk; focus on LDL particle size + inflammation.
BDNF (rs6265 TT): Met/Met — reduced plasticity; aerobic exercise and novel learning particularly important.
CYP2C9 (rs1057910 AC): Intermediate — significant dose reduction often needed. Drug considerations: warfarin.
TPMT (rs1142345 TT): Poor metabolizer — standard thiopurine doses can cause fatal myelosuppression. Requires dose reduction or alternative therapy. Drug considerations: azathioprine, mercaptopurine, thioguanine.

Athletic Performance & Recovery

ACTN3
normal
CT · rs1815739
RX — mixed profile.
PPARGC1A
normal
CT · rs8192678
Intermediate.
COL5A1
normal
TT · rs12722
More compliant tendons.
IL6
warning
GG · rs1800795
Higher inflammatory response — longer recovery windows may help.

Cardiovascular & Longevity

APOE
normal
TT · rs429358
Not e4 at this site.
ClinVar: risk factor — Alzheimer disease; cardiovascular disease
APOE
normal
CC · rs7412
Not e2 at this site.
ClinVar: risk factor / protective — Type III hyperlipoproteinemia (homozygous e2)
9p21
risk
GG · rs10757278
Two risk alleles — elevated CAD risk; focus on LDL particle size + inflammation.
FOXO3
normal
GT · rs2802292
Protective longevity allele present.
LPA
normal
TT · rs3798220
Not a risk carrier.

Cognition & Mood

BDNF
risk
TT · rs6265
Met/Met — reduced plasticity; aerobic exercise and novel learning particularly important.
DRD2
normal
GG · rs1800497
A2/A2 — standard D2 receptor density.
OXTR
normal
GG · rs53576
Higher reported empathy / prosocial scores.

Dietary Sensitivity & Nutrition

LCT
warning
GG · rs4988235
Lactase non-persistent — likely lactose intolerant.
CYP1A2
normal
AA · rs762551
Fast metabolizer — standard caffeine tolerance.
ALDH2
normal
GG · rs671
Normal alcohol metabolism.
FADS1
warning
GT · rs174537
Moderate conversion — marine omega-3 more important.
TAS2R38
normal
CC · rs713598
Taster — may dislike Brussels sprouts, broccoli.

Iron Metabolism (HFE)

HFE
normal
GG · rs1800562
Non-carrier.
ClinVar: pathogenic — Hereditary hemochromatosis type 1
HFE
normal
CC · rs1799945
Non-carrier.
ClinVar: risk factor — Hereditary hemochromatosis type 1 (low penetrance)
HFE
normal
AA · rs1800730
Non-carrier.
ClinVar: uncertain significance — Hereditary hemochromatosis type 1

Methylation & Detox

MTHFR
warning
AG · rs1801133
~30% reduced enzyme activity; monitor homocysteine.
ClinVar: drug response — Homocystinuria; MTHFR deficiency
MTHFR
warning
GT · rs1801131
Mild reduction; clinically meaningful only when combined with C677T variant.
ClinVar: not provided — MTHFR deficiency (compound heterozygous with C677T)
COMT
warning
GG · rs4680
Warrior phenotype — fast dopamine clearance; often higher stress resilience, lower baseline dopamine.
MTR
normal
AA · rs1805087
Standard activity.
MTRR
warning
AG · rs1801394
Moderate reduction; paired MTR/MTRR variants amplify impact.
FUT2
normal
AA · rs602662
Secretor — standard B12 absorption.
CBS
normal
GG · rs234706
Standard activity.
VDR
warning
AA · rs2228570
Lower receptor sensitivity — may benefit from higher vitamin D intake.

Pharmacogenomics (PGx)

CYP2C19
normal
GG · rs4244285
Normal metabolizer at this site.
ClinVar: drug response — Clopidogrel response; CYP2C19-mediated drug metabolism
Clopidogrel: Consider alternative antiplatelet agent (prasugrel or ticagrelor) if no contraindication.
Citalopram: Consider 50% dose reduction or alternative SSRI.
CYP2C19
normal
CC · rs12248560
Normal.
ClinVar: drug response — CYP2C19 ultrarapid metabolism
Clopidogrel: Standard dosing; monitor for bleeding with concurrent PPI use.
Voriconazole: Subtherapeutic levels likely — consider alternative antifungal.
CYP2C9
normal
CC · rs1799853
Normal metabolizer.
ClinVar: drug response — Warfarin response; NSAID metabolism
Warfarin: Use pharmacogenomic-guided dosing algorithm (e.g. warfarindosing.org).
Celecoxib: Use lowest effective dose; consider 25-50% reduction.
CYP2C9
risk
AC · rs1057910
Intermediate — significant dose reduction often needed.
ClinVar: drug response — Warfarin response; NSAID metabolism
Warfarin: Use PGx-guided dosing; *3/*3 requires substantial dose reduction.
VKORC1
warning
CT · rs9923231
Increased sensitivity — lower starting dose.
ClinVar: drug response — Warfarin sensitivity
Warfarin: Lower initial warfarin dose (pair with CYP2C9 genotype for full algorithm).
SLCO1B1
normal
TT · rs4149056
Normal.
ClinVar: drug response — Simvastatin-induced myopathy
Simvastatin: Avoid simvastatin 80 mg; consider atorvastatin or rosuvastatin.
TPMT
risk
TT · rs1142345
Poor metabolizer — standard thiopurine doses can cause fatal myelosuppression. Requires dose reduction or alternative therapy.
ClinVar: drug response — Thiopurine S-methyltransferase deficiency
Azathioprine: Consider alternative non-thiopurine therapy; if used, reduce dose 10-fold and monitor for severe myelosuppression.
Mercaptopurine: Start at 30-80% of normal dose (heterozygote) or 10% of normal dose (homozygote).
Thioguanine: Start at 50-80% of normal dose (heterozygote) or consider alternative (homozygote).
CYP3A5
warning
CC · rs776746
Expresser — higher tacrolimus doses needed.

Stimulant & Adenosine Sensitivity

ADORA2A
normal
CC · rs5751876
Standard response.
COMT
warning
GG · rs4680
Warrior — dopamine clears fast; stimulants may feel less intense.