A Collaborative Modeling Framework for Multi-Study Coordinated Analyses

  • Andriy Koval, Andrea Piccinin, Scott Hofer (University of Victoria)
  • Graciela Muniz (University College London)
  • Will Beasley (University of Oklahoma)

IALSA network July-22-2015, Wellcome Trust Conference

Portland Workshop

  • examine associations between changes in physical functioning (i.e., grip strength, pulmonary function, chair stands, walking speed)
  • and cognitive functioning (i.e., measures of speed, memory, reasoning, executive functioning)
  • in multiple-study comparative framework using
  • bivariate growth models

Publication Model

pub

Association between changes in

Open Science & Reproducible Research

  • GitHub repository
  • no data is shared, only models
  • all scripts and reports available online
  • 1649 models submitted so far counts_table

Dashboard

dashboard

  • built with shinydashboard R package
  • interactive html interface on top of R script
  • what exactly do those number count?

About: Model ID

naming

  • each file with model output provided a unique model ID
  • ID is parsed into variables we can use in meta-analysis over studies

About: Domain Mapping

  • constructs/domains are flexible
  • here is our current organization
  • first six characters, counts domain map

Model Collective

  • counts models in each combination
  • each color adds to 100%
  • pivot table
    • study_name: EAS
    • physical_measure: grip
    • model_type: aeh
    • list unique values
    • pc_CORR_11
  • what are the key info about the model that we want to collect? (ISR)

Specification

  • random intercepts, slopes, residuals (ISR)
  • Bivariate ISR (BISR) graph

BISR

  • view for one study and one physical measure
  • variance, p-value, 95CIs Compare
  • (EAS, grip, aeh) vs. (EAS, grip, a)
  • (EAS, grip, aeh) vs. (OCTO, grip, aeh)

Forest

Compare

  • view for all studies with this physical measure
  • block : (eas,males) vs. (octo, females)
  • mmse : (octo, males) vs. (oct, females)

Future

  • IalsaSynthesis - R package to service collaborative workshops
  • add data : new models
  • add data : new studies
  • add data : new outcomes
  • add models: new specifications
  • add questions: new analyses

Thanks

  • IALSA team
  • Andrea Piccinin
  • Scott Hofer
  • Graciela Muniz
  • Will Beasley logo